Waterproof duffel bags can be made from different materials such as nylon, PVC, and tarpaulin.

Nylon is a durable and light material, but it may not be fully waterproof unless coated with PU or other materials. PVC is heavier, stiffer, and more waterproof than nylon, but it may crack and fade over time. Tarpaulin is a heavy-duty material that is highly waterproof and resistant to abrasion and puncture, but it is also heavier and less flexible.

The difference among each material mainly lies in their level of waterproofness, durability, weight, and flexibility. Some materials may be more suitable for certain activities or conditions, such as tarpaulin for rugged outdoor expeditions, or nylon for more casual use.